目前分類:未分類文章 (50)
- Jun 17 Sat 2017 15:55
Molecular pathology of lung cancer
- Jun 17 Sat 2017 14:34
Biology of lung cancer
G1->S phase: (1) suppressor (RB pathway, 和CDK相關!),(2) suppressor (p53 pathway)
Resistance to cell death (apoptosis): 主要是和p53有關
- May 27 Sat 2017 11:20
Interstitial lung disease with autoimmune disease
ILD in IM: anti-JO-1(+) -> 70% (anti-MDA5)
(IM: inflammatory myositis; Gottron's papules, mechanical hand )
- Mar 22 Wed 2017 21:46
肺癌筆記
1. IV NVB最多給到BSA 20-25, 若給到35,則容易severe neutropenia
2. 第一次打immunotherapy, 最好把時間拉長到90分鐘,不然容易anaphylactic shock, 可加0.5 amp Vena
- May 21 Sat 2016 12:31
從浩鼎學習Globo H-Based Vaccine
目前是immunotherapy對於lung cancer治療的新進程,從之,我們可以相較於breast cancer的浩鼎小故事。
原來它的疫苗是用fully synthetic glycoconjugate vaccine composed of globo H and monophosphoryl lipid A (MPLA) 來induce T cell immunity。而且他的primary end point是PFS. 今天老師上課說,目前美國FDA希望要用OS來評估,而不是用PFS。
- Jan 13 Wed 2016 18:36
抽完胸水後可以坐飛機嗎?(pneumothorax post thoracentesis)
- Nov 03 Tue 2015 19:42
pulmonary embolism 肺栓塞 病生理機轉
引自Harrison's Principles of Internal Medicine, 19e chap. 300: Deep Venous Thrombosis and Pulmonary Thromboembolism
某次內專有考這一題,pulmonary embolism的機轉:
- Oct 30 Fri 2015 17:50
Vemurafenib in non-melanoma patient (NEJM 2015)
- 針對BRAF V600E突變的病人可以使用,Melanoma約店有50%。
- 這一次NEJM想要推廣到其他疾病,如NSCLC或LCH。
- 這是phase II study,期待後續phase III study。
- Sep 25 Fri 2015 21:37
Idiopathic acute eosinophilic pneumonia
1. 首先在1989年,於acute resp. failure的case中被描述。
2. AEP與CEP不同,雖然都是肺實質有eosinophilic infiltration
- Apr 04 Sat 2015 01:12
非肺部手術之術前評估
寫這一篇文章,專門是對於骨科會診用的 = =;
PPCs(術後肺部併發症)會延長住院時間(廢話),如pneumonia, atelectasis, respiratory failure, bronchospasm and exacerbation of underlying chronic lung disease.
- Mar 22 Sun 2015 00:33
Second primary lung cancer
1. second primary lung cancer (SPLC) 的定義:
何謂第二個原發癌症(Second primary lung cancer, SPLC)呢?就是另一個獨立的惡性腫瘤,它必須是非第一個癌症轉移、非復發、非鄰近腫瘤蔓延過來。第二原發癌可分為同時性(synchronous)與異時性(metachronous)。同時性第二原發癌,是指在第一個癌症診斷後6個月內被發現的原發癌﹔而異時性第二原發癌,是指第一個癌症診斷後6個月後才發現的原發癌。
- Feb 12 Thu 2015 15:33
肺部手術之術前評估
若DLCO<60%, 看6 minute walking test是否可以到350m以上。
若運動後FVC明顯下降(比較前後的肺功能),可能是因為air-trapping (hyperdynamic compression)。
- Feb 10 Tue 2015 16:03
Pirfenidone (for IPF, phase III trial) & UIP何時會產生?
- Feb 10 Tue 2015 15:45
肺癌腦部轉移
某次蔡總教練在meeting上分享:
1. NSCLC於第一次診斷時,約有10~20%的病人會有brain mets或是leptomeningeal carcinomatosis。
- Oct 02 Thu 2014 22:06
JNC 8 高血壓治療小整理
結果今年內專就考了,果然CV已經進入GDMT (guideline directed management therapy)的時代了。
上複習班時,學長覺得JNC8的參考性較低,而且我也沒看,所以我也沒寫對,所以就把recommendations寫上來吧!
- Nov 05 Tue 2013 00:48
呼吸器讀書心得-4
(轉錄自uptodate; FROM UPTODATE-MODES OF MECHANICAL VENTILATOR)
CONTINUOUS POSITIVE AIRWAY PRESSURE — Continuous positive airway pressure (CPAP) refers to the delivery of a continuous level of positive airway pressure (持續給予呼吸道正壓). It is functionally similar to PEEP (基本上有點像PEEP). The ventilator does not cycle during CPAP, no additional pressure above the level of CPAP is provided, and patients must initiate all breaths (病人需啟始所有呼吸).
- Nov 05 Tue 2013 00:34
呼吸器讀書心得-3
(from uptodate-modes of mechanical ventilator)
PRESSURE-LIMITED VENTILATION — Pressure-limited ventilation (also called pressure-cycled ventilation)需要設定inspiratory pressure level, I:E ratio, respiratory rate, applied PEEP, and FiO2 。吸氣停止於delivery of the set inspiratory pressure後。
- Nov 01 Fri 2013 21:55
呼吸器讀書心得-2
(from uptodate-Modes of mechanical ventilation)
Volume-limited ventilation (also called volume-controlled or volume-cycled ventilation)
- Oct 19 Sat 2013 04:15
Olmetec induced sprue-like enteropathy
From FDA, Olmesartan would induce sprue-like enteropathy. The clinical symptoms/signs are long-term sever diarrhea combined with decreased body weight. The condition would be relieved if stopping this medication.
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