常常碰到tumor fever的病人，有一些症狀，如fever找不到原因(FUO)、流汗，我們就會考慮是不是tumor fever，然後就給Naproxen 0.5 tab BID使用。
以下為相關EBM資料：
1. 首先，正名，其該稱為「Neoplastic Fever」
2. 建立診斷，至少有六種相關症狀：
(1)temperature >37.88C at least once daily
(2)fever duration >2 weeks
(3)no evidence of infection (by physical examination, laboratory investigations, or imaging studies)
(4)no allergic mechanisms
(5)no response of fever to empiric antibiotics for 7 days
(6)Naproxen test resulting in complete lysis of fever, which ismaintained while on naproxen
3. 建立劑量：
naproxen 375mg orally every 12 hours for a period of 36 hours
==> 但臨床上都是用Naproxen 125mg BID
4. 是不是有其他藥物：
selective COX-2 inhibitors may be used in patients at risk for gastrointestinal toxicity and those with thrombocytopenia
以上內容引用自：
Naproxen test for neoplastic fever may reduce suffering. Alsirafy SA, El Mesidy SM, Abou-Elela EN, Elfaramawy YI. J Palliat Med. 2011 May;14(5):665-7. doi: 10.1089/jpm.2010.0402. Epub 2011 Feb 3.
以下為相關EBM資料：
1. 首先，正名，其該稱為「Neoplastic Fever」
2. 建立診斷，至少有六種相關症狀：
(1)temperature >37.88C at least once daily
(2)fever duration >2 weeks
(3)no evidence of infection (by physical examination, laboratory investigations, or imaging studies)
(4)no allergic mechanisms
(5)no response of fever to empiric antibiotics for 7 days
(6)Naproxen test resulting in complete lysis of fever, which ismaintained while on naproxen
3. 建立劑量：
naproxen 375mg orally every 12 hours for a period of 36 hours
==> 但臨床上都是用Naproxen 125mg BID
4. 是不是有其他藥物：
selective COX-2 inhibitors may be used in patients at risk for gastrointestinal toxicity and those with thrombocytopenia
以上內容引用自：
Naproxen test for neoplastic fever may reduce suffering. Alsirafy SA, El Mesidy SM, Abou-Elela EN, Elfaramawy YI. J Palliat Med. 2011 May;14(5):665-7. doi: 10.1089/jpm.2010.0402. Epub 2011 Feb 3.
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